Natalie G. Ahn (Chemistry & Biochemistry and HHMI) Control of cellular signal transduction by phosphorylation; regulatory mechanisms of enzymes in the growth factor-regulated MAP kinase pathway; use of mass spectrometry and proteomics to identify intracellular targets of kinases; NMR structural studies of kinases

Kristi S. Anseth (Chemical & Biological Engineering and HHMI) Polymers, engineering of novel biomaterials, photopolymerization of biomaterials and medical applications, computer simulation

Robert Batey (Chemistry & Biochemistry) X-ray crystallographic studies of the structures and mechanisms of ribonucleoprotein enzymes and switches, including those involved in signal recognition during membrane targetting, in biogenesis of ribosomes, and in RNA regulation

Meredith Betterton (Physics) Mathematical modeling and computational analysis of biophysical problems, including the unwinding of DNA by helicases, and the physical properties of DNA tethers used in single molecule studies

Thomas R. Cech (Chemistry & Biochemistry and HHMI) Use of X-ray crystallography to understand the folding and catalytic function of ribozymes and other large RNA molecules; combinatorial (in vitro selection) approaches; kinetic and thermodynamic analysis

Noel A. Clark (Physics) Dynamics and materials properties of nucleic acids; use of nucleic acids in the development of new liquid crystal materials and switching devices

Shelley D. Copley (Molecular, Cellular & Developmental Biology) Microbial degradation of xenobiotic pollutants; evolution, mechanism, and quality of function of enzymes recruited to serve novel functions in a new metabolic pathways; physical organic chemistry of catalytic mechanisms; catalysis in biogenesis on early Earth

Gordana Dukovic (Chemistry & Biochemistry) Nanoscience; fundamental problems and integration of light-absorbing semiconductor nanocrystals with redox enzymes and light-driven enzyme redox reactions

Joel Eaves (Chemistry & Biochemistry) Theoretical chemistry; mechanisms limiting infectivity in viruses; statistical mechanics of DNA under extreme tension and strain; genomic glass transitions in bacteriophages; mechanisms and probabilities of genomic knots; disruption of protein interactions; design principles of self-assembly; structure-function relationships of ligand-coated gold nanoparticles

Joseph J. Falke (Chemistry & Biochemistry) Biophysical chemistry; in situ spectroscopic studies of membrane-bound signaling complexes; NMR, EPR and fluorescence; novel uses of site-directed sulfhydryl chemistry to probe membrane protein structure and dynamics; prokaryotic and eukaryotic chemotaxis pathways

Dan Feldheim (Chemistry & Biochemistry) Nanomaterials; discovery of new catalyst materials for use in alternative energy schemes; development of new methods and therapeutics for the diagnosis and treatment of infectious diseases such as TB and HIV; development of new biomolecule tagging strategies for use in electron tomographic imaging of whole cells

Ryan T. Gill (Chemical &Biological Engineering) Systems biology and bioengineering including analysis and engineering of metabolic pathways, DNA array analysis of cellular pathways, development of optimized cellular systems for protein synthesis

Matt A. Glaser (Physics) Computational Physics; simulation studies of the phase behavior of idealized and atomistic models for liquid crystals in the bulk and in confined geometries; experimental and theoretical studies of molecular motor systems; self-assembly in liquid crystals, colloidal suspensions, polyelectrolytes, and biomaterials

James A. Goodrich (Chemistry & Biochemistry) Molecular mechanisms and kinetics of human mRNA transcription, transcriptional regulation, reconstitution and kinetic characterization of transcriptional complexes, FRET analysis of transcriptional complex structure and dynamics

Andreas Hoenger (Molecular, Cellular & Developmental Biology) Cryo-electron microscopy-based three-dimensional (3-D) reconstruction of large macromolecular assemblies and cellular structures, whenever possible within the context of an intact cell; microtubule structures, MAPS and molecular motors (Boulder Lab for 3-D Fine Structure)

James T. (Casey) Hynes (Chemistry & Biochemistry; Physical Chemistry) Microscopic theory and computer simulation of chemical reactions in enzyme active sites and in biological photoprocesses, focusing on proton, hydrogen atom, and hydride transfers

Ralph Jimenez (Chemistry & Biochemistry; Physical Chemistry) Protein dynamics, ultrafast laser spectroscopies for measuring dynamics on the femtosecond through nanosecond time scales, role of protein flexibility in immune system recognition

Joel Kaar (Chemical & Biological Engineering) Symbiotic interfacing of enzymes and materials; development of novel functional materials that exploit the specificity, catalytic activity, self-assembly and natural diversity of proteins

Rob Knight (Chemistry & Biochemistry) Development of new computational and experimental techniques to analyze the information contents, compositions and functions of biomolecules, genomes, and communities

Robert D. Kuchta (Chemistry & Biochemistry) Mechanistic studies of DNA polymerase alpha-primase, including pre-steady state and steady state kinetics, atomic force microscopy, interactions with accessory proteins. Inhibition of protein and lipid glycosylation, including inhibitor design, receptor function, and carbohydrate analysis

Leslie A. Leinwand (Molecular, Cellular & Developmental Biology) Biophysical studies of motor protein performance; formation, function and dysfunction of skeletal and cardiac muscle; components of the sarcomere including myosin heavy chain and troponin T; mutations that cause heart disease

Charles S. McHenry (Chemistry & Biochemistry) Mechanism of DNA replication; the ATP-powered assembly of the replicase on DNA; mechanism of elongation and the coordination of the activities of the leading and lagging strand halves of the replicase with the helicase and other components present at the replication fork.

J. Richard McIntosh (Molecular, Cellular & Developmental Biology) Analysis of the structure, mechanism, and regulation of the chromosomal segregation machinery; molecular, cellular, and biophysical methods; use of electron microscopy to reconstruct organellar structure in 3 dimensions (Boulder Lab for 3-D Fine Structure)

David J. Nesbitt (Chemistry & Biochemistry; Physical Chemistry; JILA) Confocal far field microscopy of single protein molecules; single molecule kinetics of substrate-protein binding; high resolution scanning optical microscopy on subnanometer length scales; single molecule fluorescence, non-linear and Raman spectroscopies

Norman R. Pace (Molecular, Cellular & Developmental Biology) Structures and mechanisms of ribonuclear proteins and enzymes, including crystallographic analysis of RNP high resolution structure, and kinetic analysis of RNP enzymes

Amy Palmer (Chemistry & Biochemistry; Biotechnology Program) Chemical biology, biosensor design, imaging of signal transduction pathways; development of novel FRET sensors and reporters; phage display, rational protein design, and peptide synthesis; spectroscopic and biophysical methods

Arthur Pardi (Chemistry & Biochemistry) Biophysical chemistry and NMR spectroscopy; high-resolution multi-dimensional NMR; structure and dynamics of biomolecules in solution; structural studies of RNA enzymes

Thomas T. Perkins (Molecular, Cellular & Developmental Biology, JILA) Single molecule analysis of biological motors using optical tweezers and single molecule spectroscopy, motor proteins involved in DNA unwinding, transcription and translation, state-of-the-art laser spectroscopy

Theodore W. Randolph (Chemical & Biological Engineering) Pressure effects on protein folding and unfolding; protein stability; protein-solvent interactions; processing and formulation of protein-based pharmaceutical products; spectroscopies including EPR, FTIR, circular dichroism, light scattering, and surface plasmon resonance

Tarek Sammakia (Chemistry & Biochemistry; Physical and Mechanistic Organic Chemistry) Mechanistic investigations of chemical and biochemical reactions that proceed with a high degree of selectivity; total synthesis of biologically active natural products; spectroscopic methods to analyze molecular structure

Ivan I. Smalyukh (Physics; Experimental Condensed Matter Physics) Soft condensed matter, liquid crystals, biomolecular materials, nanomaterials, optics and photonics; Artificial and natural order in biological systems: from liquid crystalline patterns of DNA to aligned bacteria

Marcelo Sousa (Chemistry & Biochemistry) X-ray crystallographic analysis of proteins and protein complexes; development of novel methods for high throughput protein cloning, expression, and purification; crystallographic of membrane signaling proteins

Michael H.B. Stowell (Molecular, Cellular & Developmental Biology) Electron and x-ray crystallographic structure analysis of proteins and larger protein complexes, architectural arrangement of signaling proteins and enzymes in macromolecular assemblies at the synapse, tomography and 3-D image reconstruction

Dylan J. Taatjes (Chemistry & Biochemistry) Structural and functional studies of large, multi-subunit complexes involved in gene regulation; cryo-electron microscopy; mediator complexes CRSP and ARC-L

Gia K. Voeltz (Molecular, Cellular & Developmental Biology) Organelle biogenesis; Use of electron microscopy, fluorescence and other tools to learn how membrane proteins and their partners define the shapes of cellular membranes

Xiang Wang (Chemistry & Biochemistry) Use of chemical biology methods to discover small-molecules probes with novel biological activities via state-of-the-art high-throughput screening technologies 

Deborah Wuttke (Chemistry & Biochemistry) High-resolution, heteronuclear, multi-dimensional nuclear magnetic resonance studies of biomolecules and their complexes; use of NMR and biochemical methods to probe the relationship between three-dimensional structure and function in solution

Hang (Hubert) Yin (Chemistry & Biochemistry; Biotechnology Program) Drug discovery and biotechnology; Development of molecules that modify the activities of transmembrane receptors and channels